Dabigatran etexilate (mesylate)
CAS No. : 872728-81-9
(Synonyms: BIBR 1048MS; Dabigatran etexilate methanesulfonate)
| Size | Price | Stock |
|---|---|---|
| 5mg | $45 | In-stock |
| 10mg | $65 | In-stock |
| 50mg | $108 | In-stock |
| 100mg | $140 | In-stock |
| 200mg | $210 | In-stock |
| 500mg | $308 | In-stock |
| 1g | $420 | In-stock |
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| Cat. No. : | HY-10274A |
| M.Wt: | 723.84 |
| Formula: | C35H45N7O8S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation[1].
In Vivo: Dabigatran etexilate mesylate (BIBR 1048MS; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively[1].
Dabigatran etexilate mesylate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively[1].
Dabigatran etexilate mesylate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey[1].
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