Fmoc-NH-PEG2-CH2CH2COOH
CAS No. : 872679-70-4
| Size | Price | Stock |
|---|---|---|
| 1g | $9 | In-stock |
| 5g | $35 | In-stock |
| 10g | $60 | In-stock |
| 25g | $125 | In-stock |
| 100g | $486 | In-stock |
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| Cat. No. : | HY-W040238 |
| M.Wt: | 399.44 |
| Formula: | C22H25NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG2-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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