Tpl2 Kinase Inhibitor 1
CAS No. : 871307-18-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $220 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $660 | In-stock |
| 50mg | $1100 | In-stock |
| 100mg | $1760 | In-stock |
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| Cat. No. : | HY-12358 |
| M.Wt: | 404.83 |
| Formula: | C21H14ClFN6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].
IC50 & Target:Tpl2/COT kinase/MAP3K8[1]
In Vitro:Tpl2 (Cot/MAP3K8) is a serine/threonine kinase in the MAP3K family that is upstream of MEK in the ERK pathway[1].
Tpl2 Kinase Inhibitor 1 (compound 2p) also inhibits MK2 and p38, with IC50s of 110 μM and 180 μM, respectively in A431 cells[1].
Tpl2 Kinase Inhibitor 1 inhibits lipopolysaccharide-induced TNF-a production from primary human monocytes and human whole-blood, with IC50s of 0.7 μM and 8.5 μM, respectively[1].
Cancer Osaka thyroid (COT) kinase (Tpl2) is an important regulator of pro-inflammatory cytokines in macrophages[2].
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