TTT 3002
CAS No. : 871037-95-5
| Size | Price | Stock |
|---|---|---|
| 100 mg | Get quote | |
| 250 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-111249 |
| M.Wt: | 465.50 |
| Formula: | C27H23N5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TTT 3002 is a potent and orally active FLT3 inhibitor. TTT 3002 potently inhibits FLT3 phosphorylation by activating mutations at residue D835, with an IC50 of 0.2 nM. TTT 3002 can be used for AML (acute myeloid leukemia) research[1].
In Vitro:TTT 3002 downregulates FLT3 phosphorylation (pFLT3) in Molm14 and MV4-11 cells[1].
TTT 3002 induces cell cycle arrest followed by marked induction of apoptosis[1].
In Vivo:TTT 3002 (6 mg/kg, Oral gavage, twice per day, for 2 to 4 weeks) is effective in vivo in several mouse tumor models of FLT3/ITD-associated AML (acute myeloid leukemia) with minimal toxicity[1].
TTT 3002 (6 mg/kg, Oral gavage, single) is rapidly absorbed with a biphasic maximum serum concentration (Cmax) followed by a monoexponential decay[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- TTT 3002
- Cat. No.:
- HY-111249
- Quantity:
Your information is safe with us.