Gramine
CAS No. : 87-52-5
(Synonyms: Donaxine)
| Size | Price | Stock |
|---|---|---|
| 100g | $68 | In-stock |
| 250g | $152 | In-stock |
| 500g | $286 | In-stock |
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| Cat. No. : | HY-N0166 |
| M.Wt: | 174.25 |
| Formula: | C11H14N2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].
IC50 & Target:IC50: 3.2 µM (AdipoR2), 4.2 µM (AdipoR1)[1]
In Vitro:Gramine is an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is a potential β2-AR agonist[2].
Gramine (20 μM to 1.2 nM) dose-dependently inhibits the growth of AdipoR1/adipoR2-positive cancer cell lines (MDA-MB-231 and MCF-7 cells), with IC50s of 9.6±0.9 and 0.1±0.1 μM, respectively[1].
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