Penicillin V

Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis^[1][2][3][4]. In Vitro: Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L^[2].
Penicillin V (0.002-8.0 mg/L) shows antibacterial activity for Clostridium difficile with an MIC₅₀ value of 4.0 mg/L and an MIC₉₀ value of 8.0 mg/L^[3].
Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with an MIC value of 0.016 mg/L^[4]. In Vivo: Penicillin V (0.063-0.25 mg/kg; s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle^[4].
Penicillin V (2 mg/kg; s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L·h)^[4].
Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats^[5].