SPD304
CAS No. : 869998-49-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $180 | In-stock |
| 10mg | $280 | In-stock |
| 25mg | $580 | In-stock |
| 50mg | $930 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-111255 |
| M.Wt: | 547.61 |
| Formula: | C32H32F3N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2]. IC50 & Target: IC50: 22 μM (TNFα)[1]. In Vitro: SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p?RIP3 1.4?fold compared to GA alone, and promotes caspase 8 activation[4]. In Vivo: SPD304 cannot be used in vivo due to its high toxicity[3].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- SPD304
- Cat. No.:
- HY-111255
- Quantity:
Your information is safe with us.