Fasitibant (free base)
CAS No. : 869939-83-3
| Size | Price | Stock |
|---|---|---|
| 100 mg | Get quote | |
| 250 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-106277 |
| M.Wt: | 764.78 |
| Formula: | C36H49Cl2N6O6S+ |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fasitibant (free base) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B2 (BK2) receptor antagonist. Fasitibant (free base) has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis[1].
In Vitro:Fasitibant (free base) (1 µM; 30 min) reduces BK induced PGE2 formation and COX-2 gene expression in synovial cells[1].
In Vivo:Fasitibant (free base) (100 µg; knee injection; single dose) significantly reduces the release of IL-1b, IL-6, GRO/PINC-1 synovial cytokines, the formation of PGE metabolites, the activity of myeloperoxidase (MPO) induced by Carrageenan (HY-125474) in rats, and the effect was more significant when combined with Dexamethasone (HY-14648)[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Fasitibant (free base)
- Cat. No.:
- HY-106277
- Quantity:
Your information is safe with us.