INCB9471
CAS No. : 869769-98-2
Price and Availability of
CAS No. : 869769-98-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $650 | Get quote |
| 5 mg | Get quote | |
| 10 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-14230 |
| M.Wt: | 559.67 |
| Formula: | C30H40F3N5O2 |
| Purity: | >98 % |
| Solubility: |
Introduction of
869769-98-2
:
INCB9471 is a potent, selective and orally active CCR5 antagonist. INCB9471 shows anti-HIV-1 activity[1][2].
In Vitro:INCB9471 (0-1 µM) inhibits MIP-1 induced chemotaxis of rhIL-10-treated human monocytes with an IC50 value of 4.8 nM[1].
In Vivo:Pharmacokinetic Parameters[2].
| rats | dogs | ||
| i.v. | dose iv/po (mg/kg) | 1/20 | 1/20 |
| CL (L/h/kg) | 0.62 | 0.2 | |
| Vdss (L/h) | 4.1 | 3.8 | |
| T1/2 (h) | 6 | 11 | |
| AUC (nM h) | 2898 | 7854 | |
| p.o. | Tmax (h) | 3 | 0.5 |
| Cmax(ng/mL) | 4071 | 14007 | |
| C24h (nM) | 1088 | ||
| T1/2 (h) | 12 | 17 | |
| AUC (nM h) | 55160 | 149779 | |
| F (%) | 100 | 95 |
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