Nivitol
CAS No. : 869743-37-3
(Synonyms: UP302)
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| Cat. No. : | HY-108046 |
| M.Wt: | 302.37 |
| Formula: | C18H22O4 |
| Purity: | >98 % |
| Solubility: |
Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor. Nivitol competitively and reversibly inhibits tyrosinase, suppressing melanin production. Nivitol inhibits homogentisate 1,2-dioxygenase (HGD). In human leukemia cells, Nivitol inhibits PI3K/AKT pathway phosphorylation, increases ROS, decreases mitochondrial membrane potential, and induces G2/M cell cycle arrest, apoptosis, and PINK1/Parkin-mediated mitophagy. Nivitol exhibits inhibition of tumor growth in the MV411 xenograft mouse model. Nivitol is used for research on exogenous ochronosis, hyperpigmentation, and leukemia[1][2][3][4].
In Vitro:Nivitol (UP302) is a novel, potent, competitive, and reversible mushroom tyrosinase inhibitor with a Ki of 0.3 μM; it inhibits DOPA oxidase activity in B16-F1 mouse melanoma cell homogenates with an IC50 of 12 μM[2].
Nivitol (0-62 μM; 72 h) inhibits melanin production in B16-F1 cells and primary human epidermal melanocytes with IC50 values of 15 μM and 8 μM, respectively, and exhibits no cytotoxicity at concentrations up to 62 μM[2].
Nivitol (0.05-0.1%; 4-14 days) significantly inhibits melanogenesis in reconstructed human skin[2].
Nivitol (UP302) (20-120 μM; 48 h) inhibits the growth of MV411 and K562 human leukemia cell lines[3].
Nivitol (30-120 μM; 16 h) induces ROS production and decreases mitochondrial membrane potential in MV411 and K562 cells[3].
Nivitol (40-100 μM; 16 h) induces apoptosis in MV411 and K562 cells[3].
UP302 (30-90 μM; 16 h) alters the expression of apoptosis-related proteins in MV411 and K562 cells; activates mitophagy through the PINK1/Parkin pathway; inhibits the activation of the PI3K/AKT signaling pathway[3].
UP302 (50-100 μM; 16-48 h) induces autophagy and mitophagy in MV411 and K562 cells, and UP302-induced autophagy exerts a protective effect on leukemia cells MV411 and K562[3].
In Vivo:Nivitol (UP302) (10 mg/kg; i.p.; once every two days; two weeks) significantly inhibits tumor growth in the MV411 xenograft mouse model, with favorable short-term biosafety[3].
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