JNJ-26146900
CAS No. : 868691-50-3
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| Cat. No. : | HY-123310 |
| M.Wt: | 360.35 |
| Formula: | C15H15F3N2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
JNJ-26146900 is a potent and orally active androgen receptor antagonist with a Ki value of 400nM for rat AR. JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand. JNJ-26146900 reduces prostate tumor size and prevents bone loss. JNJ-26146900 can be used in research of cancer[1].
In Vitro:JNJ-26146900 bound to the rat androgen receptor transfected into Cos-7 cells with submicromolar potency[1].
In Vivo:JNJ-26146900 (10-100 mg/kg; p.o.; mature male Sprague-Dawley rats) reduces the wet weights of both the ventral prostate and levator ani muscle as effectively[1].
JNJ-26146900 (30-100 mg/kg; p.o.) prevents prostate tumor growth in the Dunning rat model, maximally inhibiting growth at a dose of 10mg/kg. JNJ-26146900 inhibits tumor growth significantly in a CWR22-LD1 mouse xenograft model of human prostate cancer[1].
JNJ-26146900 (30 mg/kg; p.o.; mature male Sprague-Dawley rats) reduces castration-induced tibial bone loss[1].
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