S-Adenosyl-L-methionine (chloride dihydrochloride)

S-Adenosyl-L-methionine (S-Adenosyl methionine) chloride dihydrochloride is an orally active methyl group donor. S-Adenosyl-L-methionine chloride dihydrochloride is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine chloride dihydrochloride also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine chloride dihydrochloride has the potential for, cancer, liver disease and osteoarthritis research^[1][2][3]. In Vitro:S-Adenosyl-L-methionine (300 µM, 24 or 48 h) chloride dihydrochloride induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells^[4].
S-Adenosyl-L-methionine (300 µM, 24 h) chloride dihydrochloride decreases the migration of the Cal-33 and JHU-SCC-011 cells^[4].
S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) chloride dihydrochloride protects the anticancer effect of 5‑FU by regulating the expression of DNMTs^[5].
In Vivo:S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) chloride dihydrochloride prevents ASD like behaviors induced by early postnatal valproic acid exposure in young mice^[6].
S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) chloride dihydrochloride shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model^[7].