Rhodiosin
CAS No. : 86831-54-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
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| Cat. No. : | HY-N2425 |
| M.Wt: | 610.52 |
| Formula: | C27H30O16 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
Rhodiosin is a double inhibitor of CYP2D6 and AChE, and can be isolated from Rhodiolis rhodiolis root. The IC50 for CYP2D6 is 0.761 μM, and the Ki is 0.769 μM. Rhodiosin has antioxidant and neuroprotective activity and can regulate HIF-1α signaling pathway to protect the central nervous system[1][2][3][4]
IC50 & Target:IC50: 0.420 μM (cytochrome P450 2D6)[1]；57.50-2.43 μg/mL (AChE)[2]；27.77 μM (DPPH free radical scavenging)[3]
In Vitro:Rhodiosin (10 μM, 24 h) regulates the protective effect of the central nervous system by affecting the HIF-1α signaling pathway [3].
In Vivo:Rhodiosin (100 mg/kg, Oral gavage (p.o.), once a day for 10 days) can reduce MDA content in irradiated C57BL mice models and reduce liver damage induced by radiation[4].
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