Corticotropin-releasing factor (human)
CAS No. : 86784-80-7
(Synonyms: Human CRF; Human corticotropin-releasing factor)
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| Cat. No. : | HY-P0086 |
| M.Wt: | 4757.45 |
| Formula: | C208H344N60O63S2 |
| Purity: | >98 % |
| Solubility: | H2O : 25 mg/mL (ultrasonic;adjust pH to 2 with HCl) |
Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary. In Vitro: CRF increases excitability of type II dlBNST neurons through activation of the AC-cAMP-PKA pathway, thereby causing pain-induced aversive responses[1]. In Vivo: In rats injected with CRF (1 nmol/side), the time spent in the drug-paired compartment during the test session (314±22 s) is significantly shorter than time spent in that compartment during the preconditioning session (520±18 s)[1].
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