Aftin-4
CAS No. : 866893-90-5
| Size | Price | Stock |
|---|---|---|
| 2mg | $75 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1500 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111267 |
| M.Wt: | 368.48 |
| Formula: | C20H28N6O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Aftin-4 is an Amyloid-β42 (Aβ42) inducer. IC50 & Target: Amyloid-β[1] In Vitro: Aftin-4 selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM[1]. In Vivo: Aftin-4 increases Aβ1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ1-40 or Aβ1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ1-42 content, up to +216% at the highest dose tested[1].
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