3,4,5-Tricaffeoylquinic acid


CAS No. : 86632-03-3

(Synonyms: 3,4,5-triCQA)

86632-03-3
Price and Availability of CAS No. : 86632-03-3
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1mg $240 In-stock
5mg $680 In-stock
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Cat. No. : HY-N6588
M.Wt: 678.59
Formula: C34H30O15
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 86632-03-3 :

3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases[1][2]. In Vitro: 3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes[1].
3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB[1].

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