RX-3117
CAS No. : 865838-26-2
(Synonyms: TV-1360; Fluorocyclopentenylcytosine)
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $420 | In-stock |
| 10mg | $580 | In-stock |
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| Cat. No. : | HY-15228 |
| M.Wt: | 257.22 |
| Formula: | C10H12FN3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis[1][2][3].
In Vitro: RX-3117 causes both inhibition of DNA and RNA synthesis[1].
RX-3117 (11.7, 21 μM; 48 h) shows antiproliferative activity in A549, SW1573 cells[1].
RX-3117 is activated by uridine-cytidine kinase 2 (UCK2)[1].
RX-3117 (1-25 μM; 72 h) inhibits the growth of HCT-116, MDA-MB-231, PANC-1, Caki-1, MCF7, A549, MKN45, U251 cells with IC50s of 0.39, 0.18, 0.62, 0.84, 0.34, 0.34, 0.50, 0.83 μM, respectively[2].
RX-3117 (5, 10 μM; 4 days) induces cell cycle arrest at S phase and apoptosis[2].
RX-3117 (1-5 μM; 24 h) decreases the cellular amount of DNMT1 in a dose-dependent manner in MDA-MB-231[3].
In Vivo: RX-3117 (2, 10 mg/kg; i.p.; three times per week for five weeks) shows anti-tumour activity in nude mice[3].
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