Briciclib (sodium)
CAS No. : 865784-01-6
(Synonyms: ON 014185 (sodium))
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| Cat. No. : | HY-16366A |
| M.Wt: | 518.38 |
| Formula: | C19H21Na2O10PS |
| Purity: | >98 % |
| Solubility: |
Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors[1].
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