Briciclib
CAS No. : 865783-99-9
(Synonyms: ON 014185)
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $490 | In-stock |
| 100mg | $740 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16366 |
| M.Wt: | 474.42 |
| Formula: | C19H23O10PS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL |
Briciclib (ON 014185) is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib can be used for the study of hematological system tumors and solid tumors[1]. IC50 & Target:eIF4E[1] In Vitro:Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1].
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