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ON-013100


CAS No. : 865783-95-5

865783-95-5
Price and Availability of CAS No. : 865783-95-5
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Cat. No. : HY-112822
M.Wt: 394.44
Formula: C19H22O7S
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic)
Introduction of 865783-95-5 :

ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression. IC50 & Target: Cyclin D1[1]. In Vitro: ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro. ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle[2]. ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI50=6.7-11.2 nM) [3].

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