Narlaprevir
CAS No. : 865466-24-6
(Synonyms: SCH 900518)
| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | In-stock |
| 10mg | $450 | In-stock |
| 25mg | $900 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $1960 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-10300 |
| M.Wt: | 707.96 |
| Formula: | C36H61N5O7S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM[1]. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease[2]. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM[3].
IC50 & Target: Ki: 6 nM (NS3 protease) [1]
EC90: 40 nM (NS3 protease) [1]
Ki: 7 nM (ketoamide) [2]
EC90: 40 nM (replicon RNA) [2]
In Vitro: Narlaprevir (SCH 900518) potently inhibits ketoamide with a Ki value of 7 nM[2].
Narlaprevir (SCH 900518) potently inhibits replicon RNA with an EC90 value of 40 nM[2].
In Vivo: Pharmacokinetic Analysis
Narlaprevir (SCH 900518) exhibits middle oral bioavailability (rat 46%, dog 29%, monkey 46 %) following oral administration (rat 10 mg/kg, dog 3 mg/kg, monkey 3 mg/kg )[1].
Narlaprevir (SCH 900518) exhibits moderate half-lives (rat 4.8 and dog 2 h) following intravenous administration (rat 4 and dog 1 mg/kg)[1].
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- Narlaprevir
- Cat. No.:
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