Aladorian

Aladorian (ARM036; S44121) is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy^{[1][2][3][4][5]}. In Vitro:Aladorian (ARM036) produces a characteristic product ion mass spectrum when analyzed via high resolution/high accuracy mass spectrometry at a collision energy of 25 eV, with its protonated molecular ion detected at m/z 268.0639^[5]. In Vivo:Aladorian (ARM036) sodium alleviates early cardiomyopathy in juvenile golden retrievers with golden retriever muscle dystrophy, improving left ventricular longitudinal strain and normalizing RyR2 channel closed state probability and calcium handling^[2].