Islatravir
CAS No. : 865363-93-5
(Synonyms: MK-8591)
| Size | Price | Stock |
|---|---|---|
| 1mg | $88 | In-stock |
| 5mg | $210 | In-stock |
| 10mg | $330 | In-stock |
| 25mg | $580 | In-stock |
| 50mg | $780 | In-stock |
| 100mg | $1050 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-104012 |
| M.Wt: | 293.25 |
| Formula: | C12H12FN5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 3.57 mg/mL (ultrasonic;warming;heat to 60°C) |
Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IC50 & Target:EC50: 0.068 nM (HIV-1 (WT)), 0.15 nM (HIV-1 (MDR)), 3.1 nM (HIV-1 (M184V))[1] In Vitro:Islatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1].
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