FR 180204
CAS No. : 865362-74-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $117 | In-stock |
| 10mg | $187 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12275 |
| M.Wt: | 327.34 |
| Formula: | C18H13N7 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively[1]. IC50 & Target: Ki: 0.31 μM (ERK1) 0.14 μM (ERK2) In Vitro: In AP-1-transfected cells, FR180204 dose-dependently inhibits AP-1 transactivation with IC50 of 3.1 μM[1]. FR 180204 inhibits spontaneous mesothelioma cell growth[3]. In Vivo: FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice[2]. In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters[4].
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