TC-MCH 7c
CAS No. : 864756-35-4
| Size | Price | Stock |
|---|---|---|
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| 5mg | $585 | In-stock |
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| Cat. No. : | HY-107623 |
| M.Wt: | 408.47 |
| Formula: | C24H25FN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable MCH1R antagonist with an IC50 of 5.6 nM for hMCH1R[1]. TC-MCH 7c has Kis of 3.4 nM and 3.0 nM of human and mouse MCH1R, respectively[2].
IC50 & Target: IC50: 5.6 nM (hMCH1R)[1]
Ki: 3.4 nM (hMCH1R) and 3.0 nM (mouse MCH1R)[1]
In Vitro: TC-MCH 7c has an IC50 of 9.7 μM for MCH1R in [Ca2+]i mobilization[1].
TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2].
In Vivo: TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) exhibits excellent body weight reduction in a dose-dependent manner in DIO mice model[1].
TC-MCH 7c (oral; 3-30 mg/kg) with 30 mg/kg has plasma concentrations of 5.1, 1.8, and 0.7 μM at 2, 15, and 24 hours, respectively[2].
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