SB-699551
CAS No. : 864741-95-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $400 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-103100 |
| M.Wt: | 584.66 |
| Formula: | C34H47Cl2N3O |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 100 mg/mL (ultrasonic) |
SB-699551 is a potent and selective 5-HT5A antagonist with a Ki value of 5.1 μM. SB-699551 increases the phosphorylation levels of CREB and ATF1, and decreases the phosphorylation levels of AKT, PRAS40, P70S6K, FOXO1, and S6RP. SB-699551 improves drug-induced cognitive deficits. SB-699551 improves social withdrawal and forgetfulness. SB-699551 inhibits breast cancer.
IC50 & Target:5-HT5A[1]
In Vitro:SB-699551 (0.90 mg/kg; injection) reduced sound-evoked PSP (postsynaptic potential) in goldfish M cells[2].
SB-699551 (72 h) inhibited the frequency of tumor sphere-initiating cells in tumor sphere formation assays in human breast cancer cell lines MCF-7 and HCC1954 with IC50 of 0.2 and 0.3 μM, respectively[3].
SB-699551 (5-60 min) increased the phosphorylation levels of CREB and ATF1 and decreased the phosphorylation levels of AKT, PRAS40, P70S6K, FOXO1, and S6RP[4] in breast cancer cell lines (MCF-7 and MDA-MB-157)[4].
SB-699551 (10 μM) is involved in the regulation of motor output of frog spinal motor neurons and affects the amplitude of the antidromic field potential[5].
In Vivo:SB-699551 (25 mg/kg; i.p.; once daily; 3 weeks) reduced xenograft growth rate in a breast cancer xenograft model in NOD/SCID mice and synergized with Docetaxel to reduce xenograft size[3].
SB-699551 (0.3-3 mg/kg; i.p.; once) reversed drug-induced cognitive deficits in attention switching and novel object recognition tasks and improved social withdrawal in Sprague-Dawley rats[7].
SB-699551 (0.3-3 mg/kg; s.c.; once) co-treatment with Dizocilpine (HY-15084B) or Scopolamine (HY-N0296) reversed amnesia (long-term memory) in Wistar rats[8].
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