ENMD-1198
CAS No. : 864668-87-1
(Synonyms: IRC-110160)
| Size | Price | Stock |
|---|---|---|
| 5mg | $606 | In-stock |
| 10mg | $910 | In-stock |
| 25mg | $1820 | In-stock |
| 50mg | $2730 | In-stock |
| 100mg | $4095 | In-stock |
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| Cat. No. : | HY-16196 |
| M.Wt: | 311.42 |
| Formula: | C20H25NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming) |
ENMD-1198 (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-1198 is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization.
In Vitro: ENMD-1198 (0-5 μM; 24 hours) leads to a significant dose-dependent inhibition of HCC cell growth with IC50s of 2.5 μM for HUH-7 and HepG2 cells, respectively[3].
ENMD-1198 (2.5 μM; 16 hours) abrogates EGF-induced phosphorylation of Akt (HUH-7), FAK (HUH-7), p44/42 MAPK (HepG2), and STAT3 (HUH-7, HepG2)[3].
In Vivo: ENMD-1198 (200 mg/kg; p.o.; daily from day 7 to day 19) effectively inhibits growth of hepatocellular carcinoma through direct effects on the tumor cells, and also through inhibition of angiogenesis[3].
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