NAE-IN-M22
CAS No. : 864420-54-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | In-stock |
| 10mg | $410 | In-stock |
| 25mg | $850 | In-stock |
| 50mg | $1250 | In-stock |
| 100mg | $1900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-115537 |
| M.Wt: | 363.32 |
| Formula: | C20H24Cl2N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo[1].
IC50 & Target: NEDD8 activating enzyme (NAE)[1]
In Vitro: M22 (0.37-90 μM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells[1].
M22 (0.1-100 μM; 48 h) inhibits A549 cell proliferation completely at 30 µM (GI50=5.5 µM, GI90=19.3 µM)[1].
M22 (15-30 μM; 36 h) promotes apoptosis in A549 cell line[1].
In Vivo: M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts[1].
M22 (0.36-90 μM) has low acute toxicity in zebrafish model[1].
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