Meldonium (dihydrate)
CAS No. : 86426-17-7
(Synonyms: MET-88 (dihydrate); Quaterin (dihydrate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $32 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $80 | In-stock |
| 50mg | $105 | In-stock |
| 100mg | $146 | In-stock |
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| Cat. No. : | HY-B1836A |
| M.Wt: | 182.22 |
| Formula: | C6H18N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 4.85 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C);H2O : 100 mg/mL (ultrasonic) |
Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor[1][2].
IC50 & Target:IC50: 34-62 μM (human recombinant BBOX).
EC50: 21 μM (human OCTN2).
In Vitro:Meldonium (20-40 μM; 24 h) dihydrate ameliorates lung injury by targeting PFKP to regulate glycolysis, which promotes Nrf2 translocation from the cytoplasm to the nucleus to alleviate oxidative stress and mitochondrial damage under hypoxic condition[3].
In Vivo:Meldonium (50, 100, or 200 mg/kg; once daily for 3 days) dihydrate modestly attenuates hypoxia-induced lung injury in mice[3].
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