Polymyxin B nonapeptide


CAS No. : 86408-36-8

86408-36-8
Price and Availability of CAS No. : 86408-36-8
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Cat. No. : HY-106783
M.Wt: 963.13
Formula: C43H74N14O11
Purity: >98 %
Solubility: DMSO : 16.67 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL
Introduction of 86408-36-8 :

Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3]. In Vitro:Polymyxin B nonapeptide (2-32 μg/mL, 24 h) has a synergistic effect with Azithromycin (HY-17506)[1].
Polymyxin B nonapeptide (10 μg/mL) inhibits  lipopolysaccharide (HY-D1056)-induced neutrophilic activation in a concentration-dependent manner[2].
In Vivo:Polymyxin B nonapeptide (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2].

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