Methylprednisolone aceponate
CAS No. : 86401-95-8
(Synonyms: ZK 91588; MPA)
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| Cat. No. : | HY-103025 |
| M.Wt: | 472.57 |
| Formula: | C27H36O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders[1][2][3].
In Vitro:Methylprednisolone aceponate inhibits collagenase promoter activity (in HeLa cells), LPS-induced IL-12p40 secretion (in human PBMCs) and phytohemagglutinin-induced IFN-γ secretion (in human PBMCs) with IC50s of 9.3, 16.8, 15.2 nM[3].
Methylprednisolone aceponate induces MMTV promoter and TAT activities with EC50s of 21.8 and 20.5 nM respectively[3].
In Vivo:Methylprednisolone aceponate (topically applied, 50 μL,，Coroton oil-induced Evan blue edema) shows anti-inflammatory effect with an IC50 of 0.0015%, with low systemic side effect[1].
Methylprednisolone aceponate (0.0001%-0.1%, topically applied) inhibits oedema formation with ED50 of 0.002% in irritant contact dermatitis in mice and rat[3].
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