MMAF-OMe
CAS No. : 863971-12-4
(Synonyms: Monomethyl auristatin F methyl ester)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $115 | In-stock |
| 50mg | $160 | In-stock |
| 100mg | $240 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-79256 |
| M.Wt: | 745.99 |
| Formula: | C40H67N5O8 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. In Vitro: 2.5F-Fc and 2.5F-Fc-MMAF have similar IC50?values (6.9±1.1 vs. 8.3±1.3 nM, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity[1].
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