GSK598809
CAS No. : 863680-45-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
| 50mg | $960 | In-stock |
| 100mg | $1536 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19654 |
| M.Wt: | 481.51 |
| Formula: | C22H23F4N5OS |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic);1M HCl : 28.57 mg/mL (ultrasonic;adjust pH to 2 with HCl) |
GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9. IC50 & Target: pKi: DRD3[1][2]. In Vivo: Cocaine and GSK598809 each increases peak mean arterial blood pressure. Least square mean differences are significant for both doses of cocaine compared with its vehicle. Likewise, least square mean differences are significant for both doses of GSK598809 as compared with its vehicle. The experimental question of interest, that is, whether GSK598809 significantly increases cocaine effects on peak mean arterial blood pressure, is probed by a prior it tests on the means of the fitted regression model. The dose of 3 mg/kg GSK598809 significantly increases the pressor effects of 5.6 mg/kg cocaine and of 1.7 mg/kg cocaine[1].
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