Medetomidine (hydrochloride)
CAS No. : 86347-15-1
(Synonyms: MPV785)
| Size | Price | Stock |
|---|---|---|
| 5mg | $39 | In-stock |
| 10mg | $61 | In-stock |
| 25mg | $130 | In-stock |
| 50mg | $198 | In-stock |
| 100mg | $295 | In-stock |
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| Cat. No. : | HY-17034B |
| M.Wt: | 236.74 |
| Formula: | C13H17ClN2 |
| Purity: | >98 % |
| Solubility: | Ethanol : 100 mg/mL (ultrasonic);H2O : ≥ 50 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels[1][2][3][4].
In Vitro:Medetomidine (0-1 µM, 1 h) hydrochloride inhibits aldosterone release from the adrenocortical cell suspension[7].
Medetomidine (10 nM) hydrochloride activates a kicking response in Cyprids[8].
Medetomidine (1 µM) hydrochloride increases cellular cAMP production by activating β-like receptors in CHO cells[8].
In Vivo:Medetomidine (200 μg/kg, p.o. or i.m.) hydrochloride induces a sedation in cats[4].
Medetomidine (20 µg/kg, i.v.) hydrochloride shows sedative and analgesic effects in dogs[5].
Medetomidine (0.05-0.3 mg/kg, s.c.) hydrochloride protects against Diazinon-induced toxicosis in mice[6].
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