Glycocholic acid (sodium)
CAS No. : 863-57-0
| Size | Price | Stock |
|---|---|---|
| 250mg | $7 | In-stock |
| 1g | $22 | In-stock |
| 5g | $41 | In-stock |
| 10g | $50 | In-stock |
| 25g | $101 | In-stock |
| 100g | $316 | In-stock |
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| Cat. No. : | HY-N1423A |
| M.Wt: | 487.60 |
| Formula: | C26H42NNaO6 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1]. In Vitro:Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1].
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