MLS-0437605
CAS No. : 862975-18-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1350 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-123846 |
| M.Wt: | 342.35 |
| Formula: | C16H11FN4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 20.83 mg/mL |
MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs)[1]. In Vitro: MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605[1].
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