GSK319347A
CAS No. : 862812-98-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $540 | In-stock |
| 50mg | $810 | In-stock |
| 100mg | $1215 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14682 |
| M.Wt: | 469.53 |
| Formula: | C22H19N3O5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 45 mg/mL (ultrasonic) |
GSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.
IC50 & Target: IC50: 93 nM (TBK1), 469 nM (IKKε)[1]
IC50: 790 nM (IKK2)[2]
In Vitro: GSK319347A (Compound 1) inhibits TBK1 enzyme with an IC50 of 93 nM, which also translates into good cell potency (72 nM). Moreover, IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB[1]. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM[2].
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