Benztropine
CAS No. : 86-13-5
(Synonyms: Benzatropine; Benzotropine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $185 | In-stock |
| 25mg | $375 | In-stock |
| 50mg | $600 | In-stock |
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| Cat. No. : | HY-B0520 |
| M.Wt: | 307.43 |
| Formula: | C21H25NO |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Benztropine (Benzatropine; Benzotropine) is an orally active and BBB-permeable centrally acting anticholinergic agent that can be used for Parkinson's disease research[1]. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2].
In Vitro:Benztropine (0.1-10 μM; 72 h) inhibits the growth of MDA-MB-231 cells with an IC50 value about 5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine reduces the size as well as the number of mammospheres significantly in a dose-dependent manne[1].
Benztropine inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors[1].
Benztropine induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced remyelination[1].
In Vivo:Benztropine (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model[1].
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