Bafetinib
CAS No. : 859212-16-1
(Synonyms: INNO-406; NS-187)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $235 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-50868 |
| M.Wt: | 576.62 |
| Formula: | C30H31F3N8O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph+ leukemia cells. Bafetinib has antitumor activity[1][2][3].
In Vitro:Bafetinib (0.625, 1.25, 2.5 μM,24 h) inhibits the transcription of PD-L1 in lung cancer cell H292 by c-Myc[1].
In Vivo:Bafetinib (30 mg/kg/day, orally, for 10 consecutive days) inhibits the expression of PD-L1 in mouse lung cancer[1].
Bafetinib (10 mg/kg, gavage, single dose) alleviates pain in mice by inhibiting PAR2-induced TRPV4 channel activation[2].
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