Vialinin A

Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke^[1][2][3]. In Vivo:Vialinin A (1-5 mg/kg, lateral ventricular injection, single dose) alleviates cerebral ischaemia-reperfusion injury in C57BL/6JNifdc mice^[2].
Vialinin A (2 mg/kg, lateral ventricular injection, single dose) exhibits significant cognitive improvements compared to the vehicle group in C57BL/6JNifdc mice^[2].