SR-16434
CAS No. : 857262-16-9
(Synonyms: SR-16435 (free base))
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| Cat. No. : | HY-122681 |
| M.Wt: | 338.49 |
| Formula: | C22H30N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SR-16434 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor Ki=7.49; μ-Opioid receptor Ki=2.70). SR-16434 can relieve pain[1].
IC50 & Target:NOP/μ-opioid receptor[1]
In Vivo: SR 16434 (10, 30 mg/kg; s.c.; single-dose) produces dose-dependent increase in tail-flick latency and induces antinociception[1].
SR 16434 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity[1].
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