WP-1034
CAS No. : 857064-42-7
| Size | Price | Stock |
|---|---|---|
| 100 mg | Get quote | |
| 250 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-111275 |
| M.Wt: | 321.33 |
| Formula: | C18H15N3O3 |
| Purity: | >98 % |
| Solubility: |
WP-1034 is a JAK-STAT inhibitor with proapoptotic and antileukemic activity in acute myeloid leukemia (AML). WP-1034 blocks activation of Stat 3 and 5. WP-1034 induces cell cycle arrest and triggers apoptosis. WP-1034 can be used for AML research[1].
In Vitro:WP-1034 (1-6 μM, 7 days) suppresses the colony-forming growth of OCIM2 and K562 cells in a dose-dependent manner, and inhibits leukemia colony-forming cell proliferation of fresh AML cells[1].
WP-1034 (1-10 μM, 0-4 h) inhibits Stat 3 and Stat 5 phosphorylation in a time- and dose-dependent manner in OCIM2 cells, indicating that it effectively inhibits Jak-Stat signaling in AML cells[1].
WP-1034 (5 μM, 0-16 h) induces Sub-G0 phase cell cycle arrest in OCIM2 cells[1].
WP-1034 (3-6 μM) induces apoptosis in OCIM2 cells in a dose-dependent manner with caspase 3 and PARP cleavage, and this effect is blocked by the caspase inhibitor Ac-DEVD-CHO (HY-P1001)[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- WP-1034
- Cat. No.:
- HY-111275
- Quantity:
Your information is safe with us.