Sanggenon G
CAS No. : 85698-31-3
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| 1mg | $430 | In-stock |
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| Cat. No. : | HY-12372 |
| M.Wt: | 694.72 |
| Formula: | C40H38O11 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP). Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation[1].
In Vitro:Sanggenon G (14.4 μM, 24 h) enhances caspase-8, -3 and -9 cleavage, displaces caspase-9 from XIAP and sensitizes Molt3/XIAP cells to Etoposide (HY-13629)-induced apoptosis[1].
Sanggenon G not only sensitizes the XIAP-overexpressing leukemia cell line Molt3/XIAP to Etoposide (HY-13629) treatment but also different neuroblastoma cell lines endogenously expressing high XIAP levels[1].
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