CEP-14513
CAS No. : 856693-04-4
| Size | Price | Stock |
|---|---|---|
| 100 mg | Get quote | |
| 250 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-111277 |
| M.Wt: | 576.70 |
| Formula: | C34H36N6O3 |
| Purity: | >98 % |
| Solubility: |
CEP-14513 is an ALK inhibitor with an IC50 of 4 nM. CEP-14513 also inhibits insulin receptor, VEGFR2, TIE2 and DLK kinases, but does not inhibit MET, IKKβ, or CDK1/2/5. CEP-14513 induces cancer cell apoptosis. CEP-14513 is applicable to research related to non-small cell lung cancer, anaplastic large cell lymphoma, inflammatory myofibroblastic tumor, and diffuse large B-cell lymphoma[1][2].
In Vitro:CEP-14513 inhibits the proliferation of ALK-mutant cell lines, with a cellular IC50 value of 10-30 nM[1].
CEP-14513 potently inhibits purified NPM-ALK fusion kinase with an IC50 < 5 nM, while it shows no inhibitory activity against CDK1/CDK2/CDK5, MET and IKKβ[2].
CEP-14513 inhibits tyrosine phosphorylation in NPM-ALK-transformed cells, with an IC50 < 30 nM[2].
CEP-14513 selectively inhibits proliferation and colony formation of NPM-ALK-transformed cells, and induces their apoptosis, while exhibits extremely low activity against ALK-negative K562 cells[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- CEP-14513
- Cat. No.:
- HY-111277
- Quantity:
Your information is safe with us.