CEP-11981
CAS No. : 856691-93-5
(Synonyms: ESK981; BOL 303213X)
| Size | Price | Stock |
|---|---|---|
| 1mg | $350 | In-stock |
| 5mg | $1050 | In-stock |
| 10mg | $1675 | In-stock |
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| Cat. No. : | HY-16135 |
| M.Wt: | 477.56 |
| Formula: | C28H27N7O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects[1].
In Vitro:CEP-11981(1μM, 72 h) can significantly inhibit the growth of RT4 cells[1].
In Vivo:CEP-11981(2.5 mg/kg, 5 mg/kg or 10 mg/kg, oral gavage, daily, five days a week for two weeks) significantly arrested the growth of UC xenografts compared to control with no change in weight in murine xenograft model of RT4 human UC tumor[1].
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