ONO-0300302


CAS No. : 856689-51-5

856689-51-5
Price and Availability of CAS No. : 856689-51-5
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5mg $650 In-stock
10mg $1050 In-stock
25mg $2150 In-stock
50mg $3450 In-stock
100mg $5400 In-stock
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Cat. No. : HY-115450
M.Wt: 477.59
Formula: C29H35NO5
Purity: >98 %
Solubility: DMSO : 220 mg/mL (ultrasonic)
Introduction of 856689-51-5 :

ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1]. IC50 & Target: IC50: 0.086 μM (LPA1)[1] In Vitro: ONO-0300302 shows moderate stability against rat microsomes[1]. In Vivo: ONO-0300302 inhibits significantly an LPA (lysophosphatidic acid receptor)-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over 12 h[1].

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