Furegrelate
CAS No. : 85666-24-6
(Synonyms: U-63557A (free acid))
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| Cat. No. : | HY-106080 |
| M.Wt: | 253.25 |
| Formula: | C15H11NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Furegrelate (U-63557A free acid) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate is being developed as an antiplatelet agent[1][2].
In Vivo:Furegrelate (1-5 mg/kg; po) prevents blockage of the coronary artery[1].
Furegrelate (0.1-5 mg/kg; i.v.) prevents the blockage of stenosed coronary arteries caused platelet aggregation[1].
Furegrelate blunts the development of hypoxia-induced pulmonary arterial hypertension (PAH) in an established neonatal piglet model primarily by preserving the structural integrity of the pulmonary vasculature[2].
Furegrelate has a long half-life compared to several other drugs used to treat PAH, including nitric oxide and prostagcyclin analogues; And Furegrelate is highly specific to the target enzyme[2].
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