Naloxegol
CAS No. : 854601-70-0
(Synonyms: NKTR-118; AZ-13337019)
| Size | Price | Stock |
|---|---|---|
| 100 mg | Get quote | |
| 250 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-A0118 |
| M.Wt: | 651.78 |
| Formula: | C34H53NO11 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Naloxegol (NKTR-118; AZ-13337019) is an orally active peripherally acting μ-opioid receptor antagonist with a target Ki of 7.42 nM. Naloxegol inhibits the binding of opioids to μ-opioid receptors in the gastrointestinal tract, and alleviates opioid-induced gastrointestinal hypomotility, delayed transit, hypertonicity, and increased fluid reabsorption. Naloxegol is applicable to research related to opioid-induced constipation[1][2]. IC50 & Target:Opioid receptor[1] In Vitro:Naloxegol binds with high affinity to μ-opioid receptors and κ-opioid receptors and low affinity to δ-opioid receptors in vitro, with no significant activity at non-opioid targets[2]. In Vivo:Naloxegol inhibits the binding of opioids to μ-opioid receptors in the gastrointestinal tract, and alleviates the opioid-induced phenomena including slowed gastrointestinal motility and transit, hypertonicity, and increased fluid reabsorption[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Naloxegol
- Cat. No.:
- HY-A0118
- Quantity:
Your information is safe with us.