m-PEG11-Amine
CAS No. : 854601-60-8
| Size | Price | Stock |
|---|---|---|
| 100mg | $43 | In-stock |
| 250mg | $74 | In-stock |
| 1g | $283 | In-stock |
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| Cat. No. : | HY-W040222 |
| M.Wt: | 515.64 |
| Formula: | C23H49NO11 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
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