(R)-(-)-Rolipram
CAS No. : 85416-75-7
(Synonyms: (R)-Rolipram; (-)-Rolipram)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $121 | In-stock |
| 50mg | $429 | In-stock |
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| Cat. No. : | HY-16900A |
| M.Wt: | 275.35 |
| Formula: | C16H21NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. In Vitro: The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner[1].
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